Small animal look-locker inversion recovery (SALLI)

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Small animal look-locker inversion recovery (SALLI)

Introduction and purpose Cardiac T1 mapping allows for quantitative analysis of myocardial tissue properties. Pulse sequences for human applications are not suitable for in-vivo studies in small animals.The aim of this study was to develop a single magnetic resonance imaging (MRI) approach for comprehensive assessment of cardiac function and tissue properties in small animals with high heart ra...

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Assessment of Diffuse Myocardial Fibrosis in Rats Using Small Animal Look-Locker Inversion Recovery (SALLI) T1 Mapping

Background It has been shown that the concentration of gadopentetate dimeglumine (GdDTPA) in myocardium and blood can be assessed from T1 measurements, and be used to calculate the extracellular volume (ECV) of the myocardium. We hypothesized that diffuse myocardial fibrosis in a small animal model could be quantitatively assessed by measuring myocardial ECV using small animal Look-Locker inver...

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Validation of Small-Animal Look-Locker Inversion Recovery (SALLI) Cine versus Cine MR in assessment of left ventricular function

Background Small-Animal Look-Locker Inversion Recovery (SALLI) is a novel imaging method that generates simultaneously cardiac T1 maps, cine MR and inversion recovery-prepared images for high heart rates. T1 mapping by SALLI has been tested and compared with histology, however the assessment of left ventricular (LV) function has not yet been validated. Our aim was to compare the measurement of ...

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Assessment of cardiac function and myocardial morphology using small animal Look-Locker inversion recovery (SALLI) MRI in rats.

Small animal magnetic resonance imaging is an important tool to study cardiac function and changes in myocardial tissue. The high heart rates of small animals (200 to 600 beats/min) have previously limited the role of CMR imaging. Small animal Look-Locker inversion recovery (SALLI) is a T1 mapping sequence for small animals to overcome this problem. T1 maps provide quantitative information abou...

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Assessment of diffuse myocardial fibrosis in rats using small-animal Look-Locker inversion recovery T1 mapping.

BACKGROUND The concentration of gadopentetate dimeglumine in myocardium and blood can be assessed from T1 measurements and can be used to calculate the extracellular volume (ECV) of the myocardium. We hypothesized that diffuse myocardial fibrosis in a small-animal model could be quantitatively assessed by measuring myocardial ECV using small-animal Look-Locker inversion recovery T1 mapping. M...

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ژورنال

عنوان ژورنال: Journal of Cardiovascular Magnetic Resonance

سال: 2011

ISSN: 1532-429X

DOI: 10.1186/1532-429x-13-s1-p24